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Top Agent Skills for January 4, 2026

Daily rankings of Agent Skills for Claude, ChatGPT & Codex sorted by GitHub stars.

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#1
Scientific Protein Modeling (ESM) icon

Scientific Protein Modeling (ESM)

14,610

Facilitates advanced protein design, structure prediction, and representation learning using the Evolutionary Scale Modeling (ESM) toolkit.

Data Science & ML
#2
PyOpenMS Mass Spectrometry Analysis icon

PyOpenMS Mass Spectrometry Analysis

3,719

Analyzes mass spectrometry data using Python bindings for OpenMS to process complex proteomics and metabolomics workflows.

Data Science & ML
#3
Pysam Genomic Toolkit icon

Pysam Genomic Toolkit

3,719

Reads, manipulates, and writes genomic datasets including BAM, VCF, and FASTA files using a Pythonic interface to htslib.

Data Science & ML
#4
Qiskit Quantum Computing icon

Qiskit Quantum Computing

3,719

Develops, optimizes, and executes quantum circuits and algorithms across various hardware backends using the Qiskit framework.

Data Science & ML
#5
PyTorch Lightning icon

PyTorch Lightning

3,719

Streamlines deep learning development by organizing PyTorch code into scalable, modular structures for automated training and multi-GPU orchestration.

Data Science & ML
#6
PyTDC Therapeutics AI icon

PyTDC Therapeutics AI

3,719

Facilitates drug discovery and therapeutic machine learning with curated datasets, ADMET benchmarks, and molecular optimization oracles.

Data Science & ML
#7
Scikit-Learn ML Framework icon

Scikit-Learn ML Framework

3,719

Implements professional machine learning workflows in Python including classification, regression, clustering, and data preprocessing.

Data Science & ML
#8
Scikit-bio (Biological Data Analysis) icon

Scikit-bio (Biological Data Analysis)

3,719

Performs comprehensive biological data analysis including sequence manipulation, phylogenetics, and microbial ecology statistics.

Data Science & ML
#9
QuTiP Quantum Simulations icon

QuTiP Quantum Simulations

3,719

Simulates and analyzes closed and open quantum systems using the Quantum Toolbox in Python (QuTiP).

Data Science & ML
#10
Scanpy Single-Cell Analysis icon

Scanpy Single-Cell Analysis

3,719

Performs comprehensive single-cell RNA-seq analysis including quality control, clustering, and trajectory inference using the Scanpy framework.

Data Science & ML

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