OneKGP

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The OneKGP tool serves as an MCP Server providing natural language access to the vast 1000 Genomes Project dataset, hosted within the Dnaerys variant store. This Java EE service, built on Quarkus and leveraging gRPC, offers real-time querying of 3202 samples with 138 million unique variants aligned to GRCh38. It empowers users, particularly through integration with large language models, to explore and analyze genetic data for research and clinical applications, supporting various query methods and filtering options.

Características Principales

• Real-time access to 138 million unique variants and 442 billion individual genotypes.
• Filtering genetic data based on inheritance models (de novo, heterozygous dominant, homozygous recessive).
• Variant, sample, and genotype selection based on coordinates, annotations, and zygosity.
• Offers MCP over Streamable HTTP, HTTP/SSE, and STDIO transport protocols.
• Advanced filtering by VEP, ClinVar, gnomAD AF, and AlphaMissense annotations.
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Casos de Uso

• Discovering disease-associated mutations, particularly for cancer and blood-related disorders.
• Identifying individuals affected by recessive and dominant genetic conditions within the dataset.
• Conducting clinical implication analysis based on extensive genetic information.