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The AnnData skill provides specialized expertise for handling large-scale, multidimensional biological datasets, specifically those used in single-cell genomics. It guides users through the creation, manipulation, and storage of AnnData objects, which store experimental measurements alongside observation and variable metadata. This skill is essential for researchers and developers working within the scverse ecosystem, offering optimized patterns for data loading, memory-efficient processing of massive h5ad files, and seamless integration with analysis tools like Scanpy.