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This skill empowers Claude to perform complex bioinformatics workflows using the Biopython library. It provides expert guidance for manipulating biological sequences, parsing specialized file formats like FASTA and GenBank, conducting automated NCBI BLAST searches via Bio.Entrez, and analyzing 3D protein structures. Whether building phylogenetic trees or performing sequence alignments, this skill ensures Claude follows best practices for rate-limiting, data integrity, and efficient memory management in biological data processing.