ClinVar Database Integration FAQs

Question 1

Does this skill support both GRCh37 and GRCh38 genome builds?

Accepted Answer

Yes, it provides guidance for downloading and processing ClinVar VCF files mapped to both the GRCh37 and GRCh38 human genome assemblies.

Question 2

How do I access ClinVar data programmatically using this skill?

Accepted Answer

You can access ClinVar via the NCBI E-utilities API using tools like curl or Biopython, or by downloading bulk datasets (XML, VCF, or tab-delimited) directly from the NCBI FTP site.

Question 3

What do the ClinVar star ratings represent?

Accepted Answer

Star ratings indicate the review status and level of confidence: 4 stars for practice guidelines, 3 stars for expert panels, 2 stars for multiple submitters without conflicts, 1 star for single submitters, and 0 stars for no assertion criteria.

Question 4

Can I use this skill to annotate VCF files for clinical research?

Accepted Answer

Yes, this skill provides specific workflows and command-line examples using bcftools to annotate your VCF files with ClinVar clinical significance (CLNSIG) and disease names (CLNDN).

Question 5

How should I handle conflicting variant interpretations?

Accepted Answer

The skill suggests a resolution strategy prioritizing higher star ratings, examining the most recent submission dates, and consulting expert panel classifications (3 or 4 stars) when available.

ClinVar Database Integration

ClinVar Database Integration

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