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This skill provides specialized guidance for developing Python applications on Cloudflare Workers, emphasizing the modern WorkerEntrypoint class structure over legacy patterns. It enables developers to leverage the Python ecosystem at the edge, supporting everything from simple REST APIs to complex, multi-step automation via Python Workflows. The skill helps prevent common pitfalls such as synchronous I/O errors and package compatibility issues, ensuring seamless integration with Cloudflare bindings like D1, KV, and R2 while optimizing for the Pyodide-powered WASM environment.