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The COBRApy skill for Claude Code provides specialized capabilities for genome-scale metabolic modeling and systems biology research. It empowers researchers and bioinformaticians to execute complex simulations—such as Flux Balance Analysis (FBA), Flux Variability Analysis (FVA), and gene knockout studies—directly within their development environment. By providing optimized implementation patterns for loading SBML models and managing cellular constraints, this skill streamlines the process of predicting phenotypic behaviors and optimizing metabolic pathways for engineering and scientific discovery.