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This skill enables Claude to perform advanced constraint-based reconstruction and analysis (COBRA) of metabolic models. It facilitates genome-scale metabolic modeling, flux balance analysis (FBA), and flux variability analysis (FVA) to predict cellular phenotypes and guide metabolic engineering. By providing standardized patterns for model manipulation, gene knockouts, and media optimization, it allows researchers to simulate metabolic networks, identify essential genes, and explore the metabolic potential of various organisms using Python. It is an essential tool for systems biologists and metabolic engineers working with SBML models.
