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Design of Experiments (DOE) is a statistical framework that enables users to identify how multiple input factors influence output responses while minimizing the total number of experimental runs. This skill provides Claude with structured workflows for screening numerous variables, discovering hidden interactions, and mapping response surfaces to find peak performance levels. It is an essential tool for software performance tuning, machine learning hyperparameter optimization, and complex A/B/n testing where traditional one-factor-at-a-time testing is inefficient or misleading.