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This skill provides comprehensive guidance for designing robust distributed systems, helping developers navigate complex trade-offs between consistency, availability, and latency. It covers fundamental principles like the CAP and PACELC theorems, various replication and partitioning strategies, and advanced transaction patterns such as Saga and CQRS. By applying these architectural blueprints and resilience patterns, users can build global-scale applications that maintain data integrity while ensuring high availability and performance across multiple regions.