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This skill empowers bioinformatics engineers and researchers to build, deploy, and manage scalable genomics workflows on the DNAnexus platform. It provides specialized guidance for creating cloud-native apps and applets, managing large-scale sequencing data (FASTQ, BAM, VCF), and orchestrating complex analysis pipelines via the dxpy SDK. By automating configuration tasks like dxapp.json setup and dependency management, the skill helps users focus on scientific logic while ensuring robust execution on high-performance cloud infrastructure.