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The ENA Database skill empowers researchers and bioinformaticians to programmatically interact with the European Nucleotide Archive (ENA) directly through Claude. It provides a streamlined interface for querying complex metadata, accessing taxonomy records, and downloading various genomic data formats like FASTQ, FASTA, and EMBL flat files. Whether you are automating large-scale dataset retrieval via FTP or performing targeted searches for specific study accessions, this skill handles the complexities of ENA's multi-layered REST APIs, rate limiting, and data hierarchy, making it an essential tool for accelerating genomics research and pipeline integration.