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The Ensembl Database skill empowers researchers and bioinformaticians to programmatically interact with the EMBL-EBI Ensembl genome database directly through Claude. It provides a robust interface for querying gene information by symbol or ID, fetching DNA and protein sequences, performing variant effect predictions (VEP), and conducting comparative genomics across hundreds of species. This skill is essential for automating genomic research pipelines, identifying orthologs, and integrating high-quality biological data directly into AI-driven scientific workflows, ensuring efficient data retrieval with built-in best practices for rate limiting and assembly mapping.