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This skill empowers genomic researchers and bioinformaticians to interact directly with the Ensembl database, a premier resource for vertebrate genomic information. It provides seamless access to the Ensembl REST API, enabling users to perform gene symbol lookups, retrieve DNA and protein sequences, and execute complex variant effect predictions (VEP). Beyond simple queries, the skill supports comparative genomics for identifying orthologs across 250+ species and includes tools for genomic coordinate mapping between assemblies like GRCh37 and GRCh38, making it an essential utility for automating bioinformatics pipelines and data analysis workflows.