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The Experiment Design skill empowers researchers to architect high-quality studies by providing a structured framework for methodology, internal validity, and statistical rigor. It guides users through critical elements such as hypothesis formation, power analysis justification, randomization methods, and blinding protocols. By adhering to NIH rigor standards and supporting various experimental designs—from randomized controlled trials to factorial and crossover studies—this skill ensures that research plans are robust, reproducible, and ready for grant submission or pre-registration.