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The Experiment Design Checklist is a specialized Claude Code skill designed to prevent wasted research effort by enforcing rigorous upfront planning. It guides users through the entire scientific process, from crafting falsifiable hypotheses and identifying variables to establishing strong baselines and designing surgical ablations. Ideal for data scientists, ML researchers, and software engineers, it provides a standardized template covering statistical power, confound mitigation, and compute budgeting, ensuring that every experiment produces meaningful results that would satisfy a skeptical reviewer.