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The GEO Database skill empowers researchers and bioinformaticians to programmatically interface with NCBI's public repository of high-throughput gene expression data. It provides standardized patterns for searching datasets, retrieving series (GSE), samples (GSM), and platforms (GPL), and downloading processed matrix files or raw supplementary data. This skill is essential for automating transcriptomics workflows, performing meta-analyses, and integrating public genomic data into computational pipelines using tools like Biopython and GEOparse.