Can I use this skill for systematic reviews?

Yes, the skill provides specific workflows and validated bias assessment tools like Cochrane RoB 2 and ROBINS-I designed for planning and conducting systematic reviews and meta-analyses.

Does it help differentiate between surrogate and patient-important outcomes?

Absolutely. The skill guides users to prioritize clinical outcomes such as mortality, symptoms, and quality of life over laboratory biomarkers or other surrogate endpoints.

What is the PICOT framework used for in this skill?

PICOT is used to structure clinical research questions by defining the Population, Intervention, Comparator, Outcome, and Timeframe to ensure research is focused, searchable, and answerable.

How does this skill assess the quality of medical evidence?

It utilizes the GRADE (Grading of Recommendations Assessment, Development and Evaluation) framework to rate the certainty of evidence based on study design, risk of bias, consistency, and directness.

Health Science & Clinical Research

Name: Health Science & Clinical Research
Author: lyndonkl

bylyndonkl

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Ciencia de Datos y ML

Structures clinical research and evaluates health evidence using established evidence-based medicine frameworks like PICOT and GRADE.

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This skill facilitates rigorous health science research by providing a structured workflow for formulating clinical questions, selecting appropriate study designs, and assessing the quality and bias of medical evidence. It is designed for researchers, clinicians, and regulatory experts who need to synthesize high-quality evidence from systematic reviews, clinical trials, and observational studies into actionable clinical guidelines, research protocols, or regulatory dossiers.

Características Principales

8 GitHub stars
PICOT framework for precise clinical research question formulation
Evidence quality assessment using hierarchy of evidence and GRADE ratings
Structured methodology for systematic reviews and meta-analyses
Systematic risk of bias evaluation for RCTs and observational studies
Outcome prioritization distinguishing patient-important from surrogate endpoints

Casos de Uso

Conducting a systematic review and meta-analysis of clinical interventions
Designing a Phase III Randomized Controlled Trial (RCT) research protocol
Drafting evidence-based clinical practice guidelines for medical conditions

Acerca de

Características Principales

8 GitHub stars
PICOT framework for precise clinical research question formulation
Evidence quality assessment using hierarchy of evidence and GRADE ratings
Structured methodology for systematic reviews and meta-analyses
Systematic risk of bias evaluation for RCTs and observational studies
Outcome prioritization distinguishing patient-important from surrogate endpoints

Casos de Uso

Conducting a systematic review and meta-analysis of clinical interventions
Designing a Phase III Randomized Controlled Trial (RCT) research protocol
Drafting evidence-based clinical practice guidelines for medical conditions