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This skill provides comprehensive guidance for participating in the MetaNova network, a decentralized platform for pharmaceutical drug discovery on Bittensor. It helps users configure miners, develop competitive molecular search strategies using ML-guided or genetic algorithms, and optimize PSICHIC and Boltz2 scoring to maximize TAO emissions. By offering technical instructions for GPU deployment on infrastructure like Basilica and strategies for balancing affinity with chemical diversity, the skill empowers miners to achieve higher rankings and navigate complex challenge parameters effectively.