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The Open Targets Database skill allows researchers and developers to programmatically interface with the Open Targets Platform via its GraphQL API. It provides deep access to integrated datasets covering human genetics, omics, literature, and chemical data to build evidence-based target-disease associations. This skill is essential for bioinformatics workflows, enabling users to evaluate target tractability, assess safety liabilities, and explore clinical trial data for drug discovery and repurposing directly within their AI-assisted development environment.