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The Opentrons Integration skill empowers Claude to act as a digital lab assistant for autonomous scientific discovery. It provides deep domain expertise in the Opentrons Python Protocol API v2, enabling the creation of complex liquid handling protocols for Flex and OT-2 robots. The skill covers everything from deck layout and labware management to precise hardware control of thermocyclers, heater-shakers, and magnetic modules. By bridging the gap between computational experimental design and physical execution, it allows researchers to automate high-throughput tasks like PCR setup, serial dilutions, and plate replication with AI-optimized efficiency.