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PyHealth is a comprehensive Python library designed for healthcare AI, offering specialized tools for processing electronic health records (EHR), medical coding systems, and physiological signals. It provides a modular five-stage pipeline for data loading, task definition, and training state-of-the-art models like RETAIN and SafeDrug, enabling researchers and developers to build robust clinical prediction models for tasks such as mortality prediction and drug recommendation while ensuring model interpretability, fairness, and clinical validity.