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PyLabRobot is a comprehensive, pure Python SDK designed to provide a unified interface for laboratory automation across multiple hardware platforms. It enables researchers and engineers to program complex liquid handling protocols, manage deck layouts, and integrate diverse lab equipment like centrifuges and heater shakers using a single, platform-independent API. By supporting both physical hardware control and simulated environments, it facilitates the creation of reproducible, scalable, and autonomous laboratory workflows without being locked into specific hardware vendors.