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This skill provides a structured workflow for optimizing Python research code by identifying hotspots with profiling tools like cProfile or pyinstrument. It guides users through a repeatable process of measuring slow paths, applying minimal and safe fixes such as vectorization or caching, and verifying improvements with before-and-after metrics. By adhering to strict guardrails, it ensures that optimizations remain local, reversible, and data-driven without introducing unnecessary algorithmic complexity.