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The Reactome Database skill empowers researchers and developers to interact with the world's leading open-source biological pathway database directly through Claude. It provides seamless access to over 2,800 human pathways, enabling tasks such as overrepresentation analysis for gene lists, expression data mapping, and deep exploration of molecular interactions. Whether you are identifying statistically significant pathways from experimental data or visualizing disease mechanisms in the Reactome Pathway Browser, this skill simplifies complex systems biology workflows by integrating REST API calls and Python-based analysis scripts into your development environment.