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This skill empowers Claude to act as a specialized AI scientist, facilitating the systematic formulation of robust hypotheses across various scientific domains. By integrating literature synthesis from sources like PubMed with rigorous quality assessments—including falsifiability and parsimony—it helps researchers move from initial observations to structured experimental plans. Whether exploring molecular mechanisms or systemic phenomena, this skill ensures that generated hypotheses are grounded in evidence, mechanistic in nature, and accompanied by specific, measurable predictions based on the Kosmos AI framework.