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This skill transforms Claude into an autonomous AI scientist, providing a systematic framework for scientific discovery and inquiry. It guides the model through a multi-step process: from initial observation and comprehensive literature synthesis (via PubMed and web searches) to the generation of multiple competing mechanistic hypotheses. By evaluating these theories against rigorous criteria such as falsifiability and parsimony, the skill enables researchers to design robust experimental tests and formulate specific, quantitative predictions across any scientific domain.