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The Scientific Hypothesis Generation skill provides a rigorous framework for Claude to act as a research assistant, moving from initial observations to structured experimental plans. It leverages comprehensive literature synthesis—utilizing PubMed and web search—to formulate mechanistic explanations, evaluate hypothesis quality through falsifiability and parsimony, and design robust experiments. This skill is ideal for researchers, scientists, and students who need to explore competing explanations for phenomena and develop quantifiable predictions for their studies, ensuring all inquiry is grounded in existing scientific literature.