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The stc-methodology skill provides deep domain expertise for conducting population-adjusted indirect treatment comparisons (ITC). It enables Claude to assist with complex outcome regression modeling, the selection of clinical and statistical effect modifiers, and the technical nuances of covariate centering. Designed for biostatisticians and health economics researchers, this skill ensures that STC analyses—whether frequentist or Bayesian—are performed with the rigor required by health technology assessment (HTA) bodies like NICE, offering a clear framework for choosing between STC and MAIC approaches.
