Exposes OpenCRAVAT-powered variant annotation as callable tools for Model Context Protocol (MCP) clients.
Sponsored
The OpenCRAVAT MCP Server acts as a bridge, transforming the extensive variant annotation capabilities of OpenCRAVAT into callable tools accessible via the Model Context Protocol (MCP). Hosted remotely as a Cloudflare Worker, this server enables MCP clients to seamlessly discover available OpenCRAVAT annotators, examine their output schemas, and perform variant annotations using diverse inputs such as genomic coordinates (GRCh38/hg38), dbSNP rsIDs, ClinGen Allele Registry IDs (CAids), and HGVS notations. Furthermore, it incorporates SynVar to facilitate the conversion of protein missense notations into potential GRCh38 genomic HGVS changes, streamlining complex genomic analyses within an MCP client environment.
主な機能
01Discover available OpenCRAVAT annotators and inspect their output schemas
02Annotate genomic variants using GRCh38 coordinates, dbSNP rsID, or ClinGen Allele Registry ID
03Support variant annotation via HGVS (g./c./p.) notations
04Convert protein missense notations (e.g., BRAF V600E) into GRCh38 genomic HGVS changes
05Deployable as a Cloudflare Worker or runnable locally for flexible access
063 GitHub stars
ユースケース
01Integrate advanced genomic variant annotation directly into AI chat platforms like Claude and ChatGPT
02Streamline genomic research by converting protein mutations into precise GRCh38 HGVS for subsequent analysis
03Develop and test custom Model Context Protocol (MCP) clients that require robust variant annotation services
