COSMIC Cancer Database Integration

概要

The cosmic-database skill enables Claude to programmatically interface with the Catalogue of Somatic Mutations in Cancer (COSMIC), the world's most comprehensive resource for somatic mutation data. It streamlines the process of downloading curated gene lists from the Cancer Gene Census, retrieving mutational signatures, querying gene fusions, and accessing drug resistance data. Ideal for bioinformaticians and oncology researchers, this skill automates the retrieval of large-scale genomic datasets across different assemblies (GRCh38/GRCh37), facilitating seamless integration into data analysis workflows and precision medicine research.

主な機能

• Automated download of expert-curated Cancer Gene Census (CGC) data
• Integration with Python data science tools like pandas and pysam for immediate analysis
• 81 GitHub stars
• Support for mutational signature profiles including SBS, DBS, and ID signatures
• Programmatic access to millions of somatic mutations across thousands of cancer types
• Cross-assembly compatibility for both GRCh38 and GRCh37 genomic data

ユースケース

• Identifying known oncogenes and tumor suppressors for variant filtering in clinical research
• Analyzing mutational signatures to understand underlying mutational processes in specific tumor types
• Building bioinformatics pipelines that require up-to-date cancer mutation datasets