Differential TAD Analysis

This skill provides a structured workflow for identifying differentially interacting Topologically Associating Domains (TADs) between target and control samples. It automates complex bioinformatics tasks including Hi-C matrix normalization, TAD identification, and statistical comparison of intra- and inter-TAD interactions. By streamlining the use of HiCExplorer tools, it enables researchers to detect localized shifts in chromatin structure and generate high-quality visualizations of contact maps with overlaid TAD boundaries for comparative genomic studies.

主な機能

ユースケース