Can I perform custom data queries?

Yes, while the skill provides helper functions for common tasks, it also includes an execute_query function for custom GraphQL requests.

What kind of evidence is used for target-disease associations?

It integrates genetic associations, somatic mutations, known drugs, affected pathways, RNA expression, animal models, and literature text-mining.

How are association scores interpreted?

Scores range from 0 to 1, representing the relative strength of evidence from various data types, used primarily for ranking potential targets.

Does the Open Targets Database skill require an API key?

No, the Open Targets Platform GraphQL API is public and does not require authentication for programmatic access.

What entity identifiers does this skill support?

The skill supports Ensembl gene IDs for targets, Experimental Factor Ontology (EFO) IDs for diseases, and ChEMBL IDs for drugs.

Open Targets Database

Name: Open Targets Database
Author: x-cmd

byx-cmd

•

データサイエンスとML

Queries the Open Targets Platform to identify and prioritize therapeutic drug targets through human genetics and clinical evidence.

The Open Targets Database skill allows researchers and developers to programmatically interface with the Open Targets Platform via its GraphQL API. It provides deep access to integrated datasets covering human genetics, omics, literature, and chemical data to build evidence-based target-disease associations. This skill is essential for bioinformatics workflows, enabling users to evaluate target tractability, assess safety liabilities, and explore clinical trial data for drug discovery and repurposing directly within their AI-assisted development environment.

主な機能

01Perform complex data retrieval using optimized GraphQL helper functions

02Access drug mechanism of action and clinical trial phase information

03Search across Ensembl, EFO, and ChEMBL identifier systems

04Retrieve comprehensive gene annotations including tractability and safety

05Query target-disease associations with multi-source evidence scores

068 GitHub stars

ユースケース

01Drug repurposing research by identifying novel target-disease pathways

02Therapeutic target discovery and prioritization for specific disease indications

03Safety and druggability assessment for early-stage drug development

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add x-cmd/skill opentargets-database

For use in Claude.ai and ChatGPT

Download Skill