Can I find information about clinical trials?

Yes, the skill can retrieve known drugs for specific diseases, including their maximum clinical trial phase, trial status, and reported mechanism of action.

What is the Open Targets Platform?

The Open Targets Platform is a comprehensive resource that integrates genetics, omics, and clinical data to help researchers identify and prioritize potential therapeutic drug targets.

Which identifiers are used for searching targets and diseases?

The skill primarily uses Ensembl gene IDs (e.g., ENSG...) for targets, EFO IDs for diseases, and ChEMBL IDs for drugs.

Do I need an API key to use this skill?

No, the Open Targets GraphQL API used by this skill is public and does not require authentication for standard programmatic access.

How are target-disease associations scored?

Associations are ranked using a score from 0 to 1, calculated by aggregating evidence from various sources like human genetics, somatic mutations, and animal models.

Open Targets Database Integration

Name: Open Targets Database Integration
Author: Zehong-Wang

byZehong-Wang

0•

データサイエンスとML

Queries the Open Targets Platform to identify and prioritize therapeutic drug targets using genetic and clinical data.

The Open Targets Database skill enables Claude to programmatically interact with the Open Targets Platform, a comprehensive resource for systematic drug target identification and prioritization. It allows users to search for gene-disease associations, evaluate target tractability and safety, and retrieve evidence from human genetics, omics, and clinical trials. By integrating data from sources like GWAS Catalog, ChEMBL, and Expression Atlas, this skill provides a powerful toolset for bioinformaticians and researchers to validate therapeutic hypotheses and explore the drug development landscape directly within their development environment.

主な機能

01Query target-disease association scores and supporting evidence

02Assess target tractability and druggability across multiple modalities

030 GitHub stars

04Retrieve safety liabilities and genetic constraint data for specific genes

05Access comprehensive disease annotations and therapeutic area classifications

06Search for known drugs, clinical trial phases, and mechanisms of action

ユースケース

01Prioritizing therapeutic targets for specific diseases based on genetic evidence and omics data

02Identifying drug repurposing opportunities by exploring existing indications and drug mechanisms

03Conducting competitive intelligence by analyzing the clinical trial landscape for specific targets

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add zehong-wang/kosmos opentargets-database

For use in Claude.ai and ChatGPT

Download Skill