Which genome assemblies are supported by this skill?

The skill supports both the recommended GRCh38 assembly and the legacy GRCh37 assembly.

Do I need an account to use the COSMIC skill?

Yes, COSMIC requires authentication. Academic users can register for free at the COSMIC website, while commercial users require a license from QIAGEN.

What file formats does the COSMIC skill handle?

The skill manages standard bioinformatics formats including TSV, CSV, and VCF files, typically compressed with gzip.

Can I download data for specific genes?

Yes, the skill provides Python analysis patterns to download mutation exports and then filter them for specific genes like TP53 or specific roles in cancer.

Is the data provided by the skill always up to date?

The skill uses 'latest' file paths to fetch the most recent quarterly COSMIC release, but it also supports version pinning (e.g., v102) for research reproducibility.

COSMIC Cancer Database

Name: COSMIC Cancer Database
Author: Microck

byMicrock

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108

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데이터 과학 및 ML

Accesses and processes the COSMIC database for somatic mutations, Cancer Gene Census, and precision oncology research.

The COSMIC Database skill provides programmatic access to the world's most comprehensive source of somatic mutation data in human cancer. It simplifies the retrieval of curated datasets including the Cancer Gene Census, mutational signatures, and drug resistance data, offering integrated Python scripts for automated downloads and analysis. This skill is designed for bioinformaticians and researchers who need to integrate high-quality cancer genomics data into their pipelines, facilitating tasks like variant annotation, gene role identification, and mutational signature profiling across multiple genome assemblies.

주요 기능

01Retrieval of mutational signature profiles (SBS, DBS, and ID signatures)

02Support for both GRCh38 and GRCh37 genome assemblies

03Pre-built Python patterns for filtering and analyzing genomics data

04108 GitHub stars

05Expert-curated access to the Cancer Gene Census for known oncogenes

06Automated downloading of comprehensive mutation files in TSV and VCF formats

사용 사례

01Filtering genomic variants by cancer relevance using the Cancer Gene Census

02Integrating somatic mutation data into bioinformatics and precision medicine pipelines

03Analyzing drug resistance mutations with detailed clinical annotations

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add microck/ordinary-claude-skills cosmic-database

For use in Claude.ai and ChatGPT

Download Skill