Does this skill provide access to drug resistance data?

Yes, you can specifically query and download the CosmicResistanceMutations dataset which includes clinical annotations for drug resistance.

How do I ensure I am using the most recent data?

The skill uses a 'latest' tag in file paths by default, ensuring you access the most recent quarterly release from COSMIC.

Which genome assemblies are supported by this skill?

The skill supports both GRCh38 (the current standard) and GRCh37 (legacy) genome assemblies.

Can I download data in VCF format?

Yes, the skill allows you to download mutation data in multiple formats, including TSV, CSV, and VCF for use with standard bioinformatics tools.

Do I need an account to use the COSMIC Database skill?

Yes, COSMIC requires authentication. Academic users can register for free at the COSMIC website, while commercial users require a license.

COSMIC Cancer Database

Name: COSMIC Cancer Database
Author: Activer007

byActiver007

데이터 과학 및 ML

Accesses the COSMIC database to retrieve somatic mutations, cancer gene data, and mutational signatures for oncology research.

소개

The COSMIC Database skill provides Claude with programmatic access to the world's most comprehensive resource for exploring somatic mutations in human cancer. It enables researchers and bioinformaticians to automate the retrieval of high-quality genomic data, including the Cancer Gene Census, mutational signatures, and structural variants. By integrating this skill, users can seamlessly download and filter millions of mutations across thousands of cancer types, specify genome assemblies (GRCh37/GRCh38), and incorporate clinical annotations directly into their bioinformatics pipelines for precision oncology and drug resistance analysis.

주요 기능

0 GitHub stars
Programmatic access to the complete Catalogue of Somatic Mutations in Cancer
Dual-assembly support for both GRCh37 and GRCh38 reference genomes
Support for mutational signatures including SBS, DBS, and ID profiles
Automated retrieval of the expert-curated Cancer Gene Census list
Integrated filtering for drug resistance mutations and gene fusions

사용 사례

Automating the collection and preprocessing of mutation data for bioinformatics pipelines
Identifying known oncogenes and tumor suppressors for variant prioritization
Retrieving mutational signature definitions for genomic profiling and research

소개

주요 기능

0 GitHub stars
Programmatic access to the complete Catalogue of Somatic Mutations in Cancer
Dual-assembly support for both GRCh37 and GRCh38 reference genomes
Support for mutational signatures including SBS, DBS, and ID profiles
Automated retrieval of the expert-curated Cancer Gene Census list
Integrated filtering for drug resistance mutations and gene fusions

사용 사례

Automating the collection and preprocessing of mutation data for bioinformatics pipelines
Identifying known oncogenes and tumor suppressors for variant prioritization
Retrieving mutational signature definitions for genomic profiling and research