Can I use this skill for oncology drug target validation?

Yes, it is specifically designed to help identify cancer-specific vulnerabilities and validate whether a gene is essential in specific cancer lineages or mutation contexts.

What is the significance of Chronos scores in this skill?

Chronos scores represent gene essentiality where more negative values indicate stronger dependency. Scores below -0.5 indicate likely dependency, and scores below -1 represent common essential genes.

What datasets does the DepMap skill access?

The skill accesses CRISPR Chronos scores, RNAi DEMETER2 data, PRISM drug sensitivity, and various omics datasets including mRNA expression, somatic mutations, and copy number variations.

Does this skill require a DepMap API key?

No, it utilizes the public DepMap Portal API and public data downloads which do not typically require an individual API key for standard research queries.

DepMap Cancer Dependency Analysis

Name: DepMap Cancer Dependency Analysis
Author: Yezez9

byYezez9

0•

데이터 과학 및 ML

Queries the Cancer Dependency Map to identify gene essentiality, drug sensitivity, and synthetic lethal interactions in cancer cell lines.

This skill integrates the Broad Institute's Cancer Dependency Map (DepMap) project into Claude's workflow, enabling researchers to systematically characterize genetic dependencies across hundreds of cancer cell lines. It provides specialized functions for querying CRISPR Chronos scores, RNAi data, and PRISM compound sensitivity, helping users identify therapeutic targets, discover biomarkers, and validate oncology drug candidates through automated data retrieval and analysis of genomic features like mutations and expression profiles.

주요 기능

01Identify selective dependencies and synthetic lethal interactions for target validation

02Perform co-essentiality analysis to find genes with similar biological pathways

030 GitHub stars

04Analyze biomarkers by correlating gene effects with somatic mutations and copy numbers

05Interface with the DepMap Portal API and manage large-scale omics data downloads

06Retrieve CRISPR Chronos and RNAi gene dependency scores across cancer lineages

사용 사례

01Validating if a gene is essential for survival in cancer cell lines with specific mutations

02Predicting drug sensitivity based on cell line genomic features and PRISM data

03Screening for synthetic lethal partners in cell lines with specific genetic deletions

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add yezez9/research-agent depmap

For use in Claude.ai and ChatGPT