Queries the GTEx portal to analyze tissue-specific gene expression, eQTLs, and genetic regulatory mechanisms.
The GTEx Database skill provides specialized capabilities for interacting with the Genotype-Tissue Expression (GTEx) project, a comprehensive resource for studying tissue-specific gene expression and genetic regulation across 54 human tissues. It enables researchers to interpret GWAS loci by identifying regulatory variants (eQTLs and sQTLs), explore median expression levels (TPM) across various tissues, and perform colocalization analyses. By automating API interactions with the GTEx v10 portal, it streamlines workflows for understanding how genetic variations influence gene activity in both health and disease contexts.
주요 기능
01Query median gene expression levels (TPM) across 54 human tissues
02Retrieve comprehensive lists of eGenes by specific tissue types
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04Convert GWAS variants to GTEx-compatible variant ID formats (GRCh38)
05Identify significant eQTLs and sQTLs for specific genes or variants
06Access detailed tissue metadata and dataset information for GTEx v8 and v10
사용 사례
01Interpreting non-coding GWAS variants by identifying their regulated target genes
02Comparing gene expression profiles across multiple human tissues for biological insight
03Performing multi-tissue eQTL analysis to find variants affecting expression in diverse sites
