Can I use this for drug repurposing research?

Yes, the skill can identify existing drugs for specific diseases, their mechanisms of action, and their current clinical trial phases to find new therapeutic opportunities.

How does this skill access scientific data?

The skill uses the Open Targets GraphQL API (v4) to programmatically retrieve target, disease, and drug information without requiring API keys or authentication.

What is the Open Targets Platform?

The Open Targets Platform is a comprehensive resource that integrates genetics, omics, and clinical data to systematically identify and prioritize therapeutic drug targets.

What identifiers are used for searching?

The skill supports Ensembl gene IDs for targets, EFO (Experimental Factor Ontology) IDs for diseases, and ChEMBL IDs for drugs.

What types of evidence does the skill provide?

It retrieves evidence from various sources including genetic associations (GWAS), somatic mutations, known drugs, affected pathways (CRISPR), RNA expression, and animal models.

Open Targets Drug Discovery

Name: Open Targets Drug Discovery
Author: ricable

byricable

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데이터 과학 및 ML

Accesses the Open Targets Platform to identify therapeutic targets, analyze disease associations, and evaluate drug tractability.

소개

This skill integrates the Open Targets Platform into the Claude workflow, enabling systematic identification and prioritization of potential therapeutic drug targets. By leveraging a comprehensive GraphQL interface, users can query high-quality datasets covering human genetics, omics, literature, and clinical data to build evidence-based associations. It is an essential tool for researchers and developers needing to assess target druggability, explore safety liabilities, and conduct competitive intelligence within the drug development landscape directly through AI-guided analysis.

주요 기능

Retrieve supporting evidence from genetics, pathways, and literature
Search for specific Ensembl, EFO, and ChEMBL identifiers
Query target-disease associations with multi-source evidence scores
Assess gene tractability, safety liabilities, and genetic constraints
1 GitHub stars
Identify known drugs, clinical trial phases, and mechanisms of action

사용 사례

Assessing the safety and druggability profiles of potential gene targets
Therapeutic target identification and prioritization for specific diseases
Researching drug repurposing opportunities through clinical precedence analysis

소개

주요 기능

Retrieve supporting evidence from genetics, pathways, and literature
Search for specific Ensembl, EFO, and ChEMBL identifiers
Query target-disease associations with multi-source evidence scores
Assess gene tractability, safety liabilities, and genetic constraints
1 GitHub stars
Identify known drugs, clinical trial phases, and mechanisms of action

사용 사례

Assessing the safety and druggability profiles of potential gene targets
Therapeutic target identification and prioritization for specific diseases
Researching drug repurposing opportunities through clinical precedence analysis