Pysam is a specialized Claude Code skill designed for bioinformatics workflows, providing high-performance access to genomic datasets through the htslib library. It enables seamless reading, writing, and manipulation of common sequencing formats such as SAM/BAM/CRAM alignments, VCF/BCF variant records, and FASTA/FASTQ reference sequences. This skill is particularly useful for building NGS data processing pipelines, calculating read coverage via pileup analysis, and performing region-based queries on indexed genomic files, all while adhering to Pythonic 0-based coordinate conventions.
주요 기능
01Random access to indexed FASTA and FASTQ sequences
02Integrated wrappers for samtools and bcftools commands
03Read and write SAM/BAM/CRAM alignment files
04Process VCF/BCF variant files and genotype data
05Calculate genomic coverage and perform pileup analysis
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