Does the skill support data visualization?

Yes, it includes specialized Python scripts to generate Michaelis-Menten plots, pH/temperature activity profiles, and heatmaps using Matplotlib and Seaborn.

Can I compare enzymes across different species?

Absolutely, the skill includes helper functions specifically designed to compare parameters like optimal pH, temperature, and affinity constants across various organisms.

Does this skill require a BRENDA account?

Yes, you must register for a free account at the official BRENDA website and provide your credentials via the BRENDA_EMAIL and BRENDA_PASSWORD environment variables.

What kind of kinetic data can I retrieve?

You can access a wide range of data including Michaelis constants (Km), turnover numbers (kcat), Vmax, inhibitor constants (Ki), and IC50 values for specific substrates.

BRENDA Enzyme Database Explorer

Name: BRENDA Enzyme Database Explorer
Author: plurigrid

byplurigrid

•

Data Science & ML

Accesses the comprehensive BRENDA enzyme database via SOAP API to retrieve kinetic parameters, reaction equations, and biochemical data for metabolic research.

This skill integrates the official BRENDA (BRaunschweig ENzyme DAtabase) API into the Claude Code environment, enabling researchers and bioinformaticians to programmatically query over 45,000 enzymes. It facilitates the retrieval of critical kinetic data like Km and kcat values, substrate specificities, and optimal environmental conditions across diverse organisms. Whether you are reconstructing metabolic pathways, performing enzyme engineering, or building kinetic models, this skill provides specialized tools to extract, parse, and visualize complex biochemical data directly within your development workflow.

Key Features

018 GitHub stars

02Compare enzyme properties and optimal conditions across multiple organisms simultaneously.

03Analyze substrate specificity, cofactor requirements, and inhibition/activation data.

04Retrieve detailed reaction equations and stoichiometry for biochemical transformations.

05Query kinetic parameters (Km, kcat, Vmax) by EC number, organism, or substrate.

06Generate kinetic plots and Michaelis-Menten visualizations for enzyme analysis.

Use Cases

01Metabolic pathway reconstruction and retrosynthesis for synthetic biology projects.

02Enzyme engineering to identify thermophilic or pH-stable homologs for industrial applications.

03Parameterizing kinetic models for systems biology and flux balance analysis (FBA).

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add plurigrid/asi brenda-database

For use in Claude.ai and ChatGPT

Download Skill