Does the ClinPGx skill require an API key?

No, the ClinPGx REST API does not require authentication for basic access, though users should respect the rate limit of 2 requests per second.

What kind of genetic data can I retrieve with this skill?

You can access information on pharmacogenes (like CYP2D6 and CYP2C19), specific allele functions, population frequencies, and variants (rsIDs) associated with drug response.

Can this skill provide dosing recommendations?

Yes, it can retrieve evidence-based dosing recommendations from the Clinical Pharmacogenetics Implementation Consortium (CPIC) based on a patient's phenotype or genotype.

What is ClinPGx and how does it relate to PharmGKB?

ClinPGx is the clinical successor to the PharmGKB database, consolidating data from PharmGKB, CPIC, and PharmCAT to provide a unified resource for clinical pharmacogenomics.

ClinPGx Pharmacogenomics Database

Name: ClinPGx Pharmacogenomics Database
Author: ricable

byricable

•

Data Science & ML

Accesses comprehensive pharmacogenomics data for precision medicine, genotype-guided dosing, and clinical decision support.

About

ClinPGx is a specialized skill for Claude Code that provides direct access to the successor of the PharmGKB database. It allows developers and researchers to programmatically query gene-drug interactions, CPIC guidelines, and allele function data essential for precision medicine. By integrating this skill, Claude can assist in analyzing how genetic variations affect medication response, interpret population allele frequencies, and retrieve regulatory drug labeling from the FDA and EMA to support evidence-based clinical dosing decisions.

Key Features

Retrieve curated gene-drug pairs and clinical annotations with graded evidence levels.
Search pharmacogenomic drug labels from global regulatory bodies like the FDA.
1 GitHub stars
Query evidence-based CPIC clinical guidelines for genotype-guided dosing.
Access allele function, phenotype assignment, and population frequency data.
Explore pharmacokinetic and pharmacodynamic pathways for drug metabolism analysis.

Use Cases

Building clinical decision support systems for personalized medicine applications.
Conducting research on drug metabolism and potential adverse drug reactions (ADRs).
Automating the interpretation of genetic test results for pharmacogenomic reporting.

About

Key Features

Retrieve curated gene-drug pairs and clinical annotations with graded evidence levels.
Search pharmacogenomic drug labels from global regulatory bodies like the FDA.
1 GitHub stars
Query evidence-based CPIC clinical guidelines for genotype-guided dosing.
Access allele function, phenotype assignment, and population frequency data.
Explore pharmacokinetic and pharmacodynamic pathways for drug metabolism analysis.

Use Cases

Building clinical decision support systems for personalized medicine applications.
Conducting research on drug metabolism and potential adverse drug reactions (ADRs).
Automating the interpretation of genetic test results for pharmacogenomic reporting.