What data sources does the ClinPGx skill use?

It consolidates data from PharmGKB, CPIC, and PharmCAT, providing a unified clinical pharmacogenomics resource for information on how genetic variation affects medication response.

Does the ClinPGx API require authentication?

Basic access to the ClinPGx REST API does not require authentication, though users should adhere to the rate limit of 2 requests per second.

Can this skill help with genotype-guided dosing?

Yes, it provides direct access to evidence-based CPIC guidelines and regulatory drug labels (FDA/EMA) that offer specific dosing recommendations based on a patient's genotype or phenotype.

What types of genes are covered in this database?

The database covers key pharmacogenes including CYP450 enzymes (like CYP2D6, CYP2C19), transporters (SLCO1B1), and HLA genes associated with severe adverse drug reactions.

ClinPGx Pharmacogenomics Database

Name: ClinPGx Pharmacogenomics Database
Author: Zehong-Wang

byZehong-Wang

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Data Science & ML

Accesses comprehensive clinical pharmacogenomics data to guide precision medicine and genotype-based dosing decisions.

The ClinPGx Database skill empowers developers and researchers to integrate deep pharmacogenomic insights into their applications using data from PharmGKB, CPIC, and PharmCAT. It provides programmatic access to curated gene-drug interactions, evidence-based clinical guidelines, and detailed allele functional data, making it an essential tool for building clinical decision support systems, conducting population-scale genomic research, or identifying genetic risk factors for adverse drug reactions. By connecting Claude directly to the ClinPGx REST API, users can automate the interpretation of genetic variants and retrieve high-level evidence for medication management.

Key Features

01Retrieve allele functional status and population frequency data

02Analyze pharmacokinetic and pharmacodynamic pathways for medications

03Access evidence-based CPIC clinical practice guidelines

04Explore regulatory pharmacogenomic drug labeling from FDA and EMA

05Query extensive gene-drug interactions and clinical annotations

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Use Cases

01Building clinical decision support tools for personalized drug dosing

02Automating the interpretation of genetic panels for pharmacogenomic reports

03Conducting safety assessments to identify genetic risks for drug toxicity

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add zehong-wang/kosmos clinpgx-database

For use in Claude.ai and ChatGPT

Download Skill