Ensembl Genome Database Access

About

This skill empowers Claude to interact directly with the Ensembl genome database, a premier resource for vertebrate genomics maintained by EMBL-EBI. It facilitates complex bioinformatics tasks such as gene ID mapping, sequence retrieval (DNA, cDNA, protein), variant consequence prediction via VEP, and cross-species comparative analysis. Whether you are building genomic research pipelines or performing ad-hoc data lookups, this skill provides the necessary patterns and best practices for efficient, rate-limit-aware API communication across multiple genome assemblies.

Key Features

• Comprehensive gene lookup by symbol, Ensembl ID, or external identifiers
• High-fidelity sequence retrieval for DNA, transcripts, and proteins
• Genetic variant analysis and functional consequence prediction via VEP
• Automated coordinate conversion between genome assemblies (e.g., GRCh37 to GRCh38)
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• Comparative genomics tools to identify orthologs and paralogs

Use Cases

• Analyzing the functional impact of genetic variants in clinical or population studies
• Performing cross-species evolutionary analysis to identify conserved genomic features
• Automating gene annotation and sequence retrieval pipelines for bioinformatics research