ESM Protein Language Models

About

ESM (Evolutionary Scale Modeling) provides a comprehensive toolkit for protein language models, enabling researchers and developers to design novel proteins, predict 3D structures, and generate efficient embeddings. By integrating ESM3 for multimodal generative design across sequence, structure, and function, and ESM C for representation learning, this skill facilitates complex biological tasks such as inverse folding, functional annotation, and high-throughput protein engineering using both local models and the scalable Forge API.

Key Features

• 8 GitHub stars
• Multimodal generative protein design using ESM3
• Scalable inference via local models or the cloud-based Forge API
• High-fidelity protein sequence embeddings with ESM C
• Automated structure prediction and inverse folding capabilities
• Function-conditioned sequence generation and annotation

Use Cases

• Designing novel proteins with specific functional or structural properties
• Generating protein variants for engineering and activity screening
• Extracting biological features for downstream machine learning classification