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InterPro Database

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Data Science & ML

Queries the InterPro REST API to analyze protein domain architectures, functional families, taxonomic distributions, and PDB 3D structures.

The InterPro Database skill equips Claude with programmatic access to EMBL-EBI's unified protein signature resource, combining data across 13 member databases like Pfam, PANTHER, SMART, and CDD. It allows researchers and computational biologists to search homologous superfamilies, map protein domain coordinates by UniProt accession, perform comparative architecture analysis, inspect taxonomic distributions, and retrieve linked experimental structures from the PDB. This skill is ideal for bioinformatics workflows requiring accurate, automated structural and functional protein classification directly through Python-based REST queries.

Key Features

01Map member database signatures across Pfam, PANTHER, SMART, CDD, and PROSITE
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03Identify protein domain architecture and coordinates via UniProt accession
04Search InterPro signatures by keyword and filter by domain, family, or superfamily
05Extract taxonomic distributions of proteins associated with specific domains
06Cross-reference domain architectures with experimental 3D structures in the PDB

Use Cases

01Comparative domain architecture analysis between orthologous or paralogous proteins
02Annotating uncharacterized protein sequences with functional domains and GO terms
03Retrieving structural PDB complexes and taxonomic lineage data for specific protein families