Is an API key required for the InterPro API?

No, the EMBL-EBI InterPro REST API is public and does not require an API key, though it is recommended to implement rate limiting for batch queries.

What member databases are included in InterPro?

InterPro integrates signatures from 13 databases, including Pfam, PANTHER, PRINTS, ProSite, SMART, TIGRFAM, SUPERFAMILY, and CDD.

Can I use this skill for novel protein sequences?

Yes, while it primarily uses UniProt IDs, it provides the framework to characterize sequences through domain architecture analysis and functional site mapping via the InterPro API.

How does this skill help with Gene Ontology (GO) mapping?

The skill retrieves GO terms directly associated with specific InterPro entries, facilitating automated functional annotation for proteins.

InterPro Protein Analysis

Name: InterPro Protein Analysis
Author: henriquescastilho

byhenriquescastilho

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Data Science & ML

Queries the InterPro database to retrieve protein functional annotations, domain architectures, and family classifications.

This skill integrates the comprehensive InterPro resource from EMBL-EBI into Claude, allowing for deep analysis of protein sequences and families. It provides access to signatures from 13 member databases like Pfam, PANTHER, and SMART, enabling users to predict protein functions, visualize domain architectures, and map Gene Ontology (GO) terms. It is an essential tool for bioinformaticians and researchers who need to characterize novel sequences or perform comparative evolutionary analysis directly within their coding environment using standardized REST API workflows.

Key Features

01Automated Gene Ontology (GO) term annotation mapping

021 GitHub stars

03Access to 13 integrated member databases including Pfam and SMART

04Support for UniProt protein lookups and batch characterization

05Detailed protein domain architecture and site mapping

06Functional prediction and classification for uncharacterized proteins

Use Cases

01Characterizing the function and domains of novel or uncharacterized protein sequences

02Mapping proteins to specific Gene Ontology terms for functional enrichment analysis

03Performing comparative evolutionary analysis through domain composition comparison

Key Features

01Automated Gene Ontology (GO) term annotation mapping

021 GitHub stars

03Access to 13 integrated member databases including Pfam and SMART

04Support for UniProt protein lookups and batch characterization

05Detailed protein domain architecture and site mapping

06Functional prediction and classification for uncharacterized proteins

Use Cases

01Characterizing the function and domains of novel or uncharacterized protein sequences

02Mapping proteins to specific Gene Ontology terms for functional enrichment analysis

03Performing comparative evolutionary analysis through domain composition comparison