Is this skill suitable for safety assessment?

Yes, it provides access to safety liabilities, genetic constraint scores, and known toxicity concerns from multiple curated databases.

Can I use this for drug repurposing research?

Yes, the skill allows you to search for drugs by disease, examine their mechanisms of action, and retrieve clinical trial statuses for various indications.

Do I need an API key to use this skill?

No, the Open Targets GraphQL API used by this skill does not require authentication or an API key for standard programmatic access.

What data sources does this skill access?

It queries the Open Targets Platform, which integrates data from human genetics, omics, scientific literature, and clinical trials via their public GraphQL API.

What identifiers are used for targets and diseases?

The skill uses Ensembl gene IDs (e.g., ENSG00000012048) for targets and EFO (Experimental Factor Ontology) IDs for diseases.

Open Targets Database

Name: Open Targets Database
Author: K-Dense-AI

byK-Dense-AI

•

3,719

•

Data Science & ML

Queries the Open Targets Platform to identify therapeutic drug targets and analyze disease-target associations using human genetics and omics data.

This skill integrates the Open Targets Platform's vast dataset into Claude's workflow, enabling systematic identification and prioritization of potential drug targets. It provides programmatic access to the Open Targets GraphQL API, allowing users to evaluate target tractability, safety, and clinical precedence while gathering evidence from human genetics, pathways, and literature. It is an essential tool for computational biologists and pharmaceutical researchers performing target discovery, drug repurposing, or competitive intelligence.

Key Features

01Search disease-target associations with weighted evidence scores

02Evaluate target druggability and potential therapeutic liabilities

033,719 GitHub stars

04Retrieve drug information including clinical trial phases and mechanisms of action

05Access multi-source evidence from genetics, omics, and scientific literature

06Query target annotations for tractability, safety, and expression profiling

Use Cases

01Identifying existing drugs for repurposing through indication and mechanism analysis

02Evaluating the safety and tractability of a specific gene for drug development projects

03Prioritizing therapeutic targets for a specific disease based on human genetic evidence

Key Features

01Search disease-target associations with weighted evidence scores

02Evaluate target druggability and potential therapeutic liabilities

033,719 GitHub stars

04Retrieve drug information including clinical trial phases and mechanisms of action

05Access multi-source evidence from genetics, omics, and scientific literature

06Query target annotations for tractability, safety, and expression profiling

Use Cases

01Identifying existing drugs for repurposing through indication and mechanism analysis

02Evaluating the safety and tractability of a specific gene for drug development projects

03Prioritizing therapeutic targets for a specific disease based on human genetic evidence