Is this skill suitable for safety assessment?

Yes, it provides access to safety liabilities, genetic constraint scores, and known toxicity concerns from multiple curated databases.

Can I use this for drug repurposing research?

Yes, the skill allows you to search for drugs by disease, examine their mechanisms of action, and retrieve clinical trial statuses for various indications.

Do I need an API key to use this skill?

No, the Open Targets GraphQL API used by this skill does not require authentication or an API key for standard programmatic access.

What data sources does this skill access?

It queries the Open Targets Platform, which integrates data from human genetics, omics, scientific literature, and clinical trials via their public GraphQL API.

What identifiers are used for targets and diseases?

The skill uses Ensembl gene IDs (e.g., ENSG00000012048) for targets and EFO (Experimental Factor Ontology) IDs for diseases.

Open Targets Database

Name: Open Targets Database
Author: K-Dense-AI

byK-Dense-AI

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3,719

Data Science & ML

Queries the Open Targets Platform to identify therapeutic drug targets and analyze disease-target associations using human genetics and omics data.

About

This skill integrates the Open Targets Platform's vast dataset into Claude's workflow, enabling systematic identification and prioritization of potential drug targets. It provides programmatic access to the Open Targets GraphQL API, allowing users to evaluate target tractability, safety, and clinical precedence while gathering evidence from human genetics, pathways, and literature. It is an essential tool for computational biologists and pharmaceutical researchers performing target discovery, drug repurposing, or competitive intelligence.

Key Features

Search disease-target associations with weighted evidence scores
Evaluate target druggability and potential therapeutic liabilities
3,719 GitHub stars
Retrieve drug information including clinical trial phases and mechanisms of action
Access multi-source evidence from genetics, omics, and scientific literature
Query target annotations for tractability, safety, and expression profiling

Use Cases

Identifying existing drugs for repurposing through indication and mechanism analysis
Evaluating the safety and tractability of a specific gene for drug development projects
Prioritizing therapeutic targets for a specific disease based on human genetic evidence

About

Key Features

Search disease-target associations with weighted evidence scores
Evaluate target druggability and potential therapeutic liabilities
3,719 GitHub stars
Retrieve drug information including clinical trial phases and mechanisms of action
Access multi-source evidence from genetics, omics, and scientific literature
Query target annotations for tractability, safety, and expression profiling

Use Cases

Identifying existing drugs for repurposing through indication and mechanism analysis
Evaluating the safety and tractability of a specific gene for drug development projects
Prioritizing therapeutic targets for a specific disease based on human genetic evidence