Does this skill support ESM3 and ESM C?

Yes, it supports the ESM3 generative family for multimodal design and the ESM C family for high-quality protein representations and embeddings.

What is the ESM Claude Code skill?

It is a specialized toolkit that allows Claude to interact with Evolutionary Scale Modeling (ESM) models for protein engineering, sequence generation, and structural analysis.

Does it require the Forge API?

While it supports the Forge API for high-performance cloud inference, it also allows for local model usage using weights like esm3-sm-open-v1.

Can I perform inverse folding with this skill?

Absolutely. The skill includes capabilities to take a target structure (from a PDB file) and generate sequences that are predicted to fold into that specific structure.

Protein Modeling & Design (ESM)

Name: Protein Modeling & Design (ESM)
Author: jimmc414

byjimmc414

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324

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Data Science & ML

Empowers Claude to design, generate, and analyze protein sequences and structures using ESM3 and ESM C evolutionary scale models.

This skill integrates state-of-the-art protein language models into Claude, enabling sophisticated bioinformatics and protein engineering workflows. It provides a comprehensive toolkit for ESM3, allowing for generative multimodal design across protein sequence, structure, and function tracks, alongside ESM C for efficient representation learning and embeddings. Users can perform complex tasks such as structure prediction, inverse folding, and functional annotation through either local model execution or the cloud-based Forge API, making it an essential tool for autonomous discovery and computational biology.

Key Features

01High-quality protein representation and embeddings with ESM C

02324 GitHub stars

03Scalable cloud inference via Forge API and local model support

04Multimodal protein generation across sequence, structure, and function

05Chain-of-thought generation for iterative protein design refinement

06Inverse folding for designing sequences based on target structures

Use Cases

01Generating protein variants and screening for optimized sequence representations

02Predicting 3D coordinates and generating PDB files from amino acid sequences

03Designing novel proteins with specific functional properties like fluorescence

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add jimmc414/kosmos esm

For use in Claude.ai and ChatGPT

Download Skill