OpenCRAVAT
Exposes OpenCRAVAT-powered variant annotation as callable tools for Model Context Protocol (MCP) clients.
Exposes OpenCRAVAT-powered variant annotation as callable tools for Model Context Protocol (MCP) clients.
The OpenCRAVAT MCP Server acts as a bridge, transforming the extensive variant annotation capabilities of OpenCRAVAT into callable tools accessible via the Model Context Protocol (MCP). Hosted remotely as a Cloudflare Worker, this server enables MCP clients to seamlessly discover available OpenCRAVAT annotators, examine their output schemas, and perform variant annotations using diverse inputs such as genomic coordinates (GRCh38/hg38), dbSNP rsIDs, ClinGen Allele Registry IDs (CAids), and HGVS notations. Furthermore, it incorporates SynVar to facilitate the conversion of protein missense notations into potential GRCh38 genomic HGVS changes, streamlining complex genomic analyses within an MCP client environment.